Nature Communications (Mar 2022)
Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors
- Laura Pérez-Alós,
- Jose Juan Almagro Armenteros,
- Johannes Roth Madsen,
- Cecilie Bo Hansen,
- Ida Jarlhelt,
- Sebastian Rask Hamm,
- Line Dam Heftdal,
- Mia Marie Pries-Heje,
- Dina Leth Møller,
- Kamille Fogh,
- Rasmus Bo Hasselbalch,
- Anne Rosbjerg,
- Søren Brunak,
- Erik Sørensen,
- Margit Anita Hørup Larsen,
- Sisse Rye Ostrowski,
- Ruth Frikke-Schmidt,
- Rafael Bayarri-Olmos,
- Linda Maria Hilsted,
- Kasper Karmark Iversen,
- Henning Bundgaard,
- Susanne Dam Nielsen,
- Peter Garred
Affiliations
- Laura Pérez-Alós
- Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen
- Jose Juan Almagro Armenteros
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Johannes Roth Madsen
- Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen
- Cecilie Bo Hansen
- Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen
- Ida Jarlhelt
- Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen
- Sebastian Rask Hamm
- Viro-immunology Research Unit, Department of Infectious Diseases, Section 8632, Rigshospitalet, University of Copenhagen
- Line Dam Heftdal
- Viro-immunology Research Unit, Department of Infectious Diseases, Section 8632, Rigshospitalet, University of Copenhagen
- Mia Marie Pries-Heje
- The Heart Center, Department of Cardiology, Rigshospitalet, University of Copenhagen
- Dina Leth Møller
- Viro-immunology Research Unit, Department of Infectious Diseases, Section 8632, Rigshospitalet, University of Copenhagen
- Kamille Fogh
- Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen
- Rasmus Bo Hasselbalch
- Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen
- Anne Rosbjerg
- Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen
- Søren Brunak
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Erik Sørensen
- Blood Bank, Department of Clinical Immunology, Section 2034, Rigshospitalet, University of Copenhagen
- Margit Anita Hørup Larsen
- Blood Bank, Department of Clinical Immunology, Section 2034, Rigshospitalet, University of Copenhagen
- Sisse Rye Ostrowski
- Blood Bank, Department of Clinical Immunology, Section 2034, Rigshospitalet, University of Copenhagen
- Ruth Frikke-Schmidt
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Rafael Bayarri-Olmos
- Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen
- Linda Maria Hilsted
- Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen
- Kasper Karmark Iversen
- Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen
- Henning Bundgaard
- The Heart Center, Department of Cardiology, Rigshospitalet, University of Copenhagen
- Susanne Dam Nielsen
- Viro-immunology Research Unit, Department of Infectious Diseases, Section 8632, Rigshospitalet, University of Copenhagen
- Peter Garred
- Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-022-29225-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
This study investigates the dynamics of immunological markers after first SARS-CoV-2 vaccination dose in cohort of healthcare professionals in Denmark. Natural infection was associated with higher antibody responses, and IgG decline varied by age, sex, T-cell response, previous infection, and interval between vaccine doses.
