ETIOLOGICAL STRUCTURE OF VIRAL RESPIRATORY DISEASES IN ADULT PATIENTS WITH BRONCHIAL ASTHMA EXACERBATION AND CHRONICAL BRONCHIOLITIS OBLITERANS

V. Z. Krivitskaya; A. A. Sominina; M. A. Petrova; I. V. Amosova; V. G. Mayorovа; M. M. Pisareva; J. V. Buzitskaya; M. P. Grudinin; A. K. Golovanova; E. R. Petrova; L. F. Kovaleva; E. A. Kiseleva

doi:10.15789/2220-7619-2015-1-45-54

Инфекция и иммунитет (Apr 2015)

ETIOLOGICAL STRUCTURE OF VIRAL RESPIRATORY DISEASES IN ADULT PATIENTS WITH BRONCHIAL ASTHMA EXACERBATION AND CHRONICAL BRONCHIOLITIS OBLITERANS

V. Z. Krivitskaya,
A. A. Sominina,
M. A. Petrova,
I. V. Amosova,
V. G. Mayorovа,
M. M. Pisareva,
J. V. Buzitskaya,
M. P. Grudinin,
A. K. Golovanova,
E. R. Petrova,
L. F. Kovaleva,
E. A. Kiseleva

Affiliations

V. Z. Krivitskaya: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
A. A. Sominina: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
M. A. Petrova: Research Institute of Pulmonology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
I. V. Amosova: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
V. G. Mayorovа: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
M. M. Pisareva: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
J. V. Buzitskaya: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
M. P. Grudinin: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
A. K. Golovanova: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
E. R. Petrova: 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17, Research Institute of Influenza.
L. F. Kovaleva: Research Institute of Pulmonology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
E. A. Kiseleva: Research Institute of Pulmonology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation

DOI: https://doi.org/10.15789/2220-7619-2015-1-45-54
Journal volume & issue: Vol. 5, no. 1
pp. 45 – 54

Abstract

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Exacerbation of bronchial asthma (BA) and common deterioration of health during chronic bronchiolitis obliterans (ChBO) are associated with viral infections in adults in 64 and 83% respectively. Mixed virus-viral associations were shown in 21–25% of cases. Respiratory syncytial infections were diagnosed with the highest frequency (50%) in patients with BA. Influenza A(H1N1)pdm09 and adenoviral infections dominated in persons with ChBO in 50 and 42% of cases, respectively. Response of virus-specific IgG in patients with BA and ChBO indicates the acute course of influenza A(H1N1)pdm09 (63% of seroconversions). There were no reactions of IgG which is specific to respiratory syncytial virus in 75% of cases and to adenovirus in 83% of cases, that is the risk factor for occurrence of latent/persistent infection. Presence of structural components of respiratory syncytial virus in the upper respiratory tract had been revealed in three patients with asthma within at least 21–28 days. Respiratory syncytial viral infections and pandemic influenza A(H1N1) pdm09 in patients with BA and ChBO are characterized by the presence of an allergic component, which is indicated by the high levels of virus-specific IgE in blood. An adenoviral infection, in contrast, has no such peculiarity.

Published in Инфекция и иммунитет

ISSN: 2220-7619 (Print); 2313-7398 (Online)
Publisher: Sankt-Peterburg : NIIÈM imeni Pastera
Country of publisher: Russian Federation
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://iimmun.ru/iimm/index

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