Frontiers in Aging Neuroscience (May 2022)
Single-Channel EEG Features Reveal an Association With Cognitive Decline in Seniors Performing Auditory Cognitive Assessment
Abstract
BackgroundCognitive decline remains highly underdiagnosed despite efforts to find novel cognitive biomarkers. Electroencephalography (EEG) features based on machine-learning (ML) may offer a non-invasive, low-cost approach for identifying cognitive decline. However, most studies use cumbersome multi-electrode systems. This study aims to evaluate the ability to assess cognitive states using machine learning (ML)-based EEG features extracted from a single-channel EEG with an auditory cognitive assessment.MethodsThis study included data collected from senior participants in different cognitive states (60) and healthy controls (22), performing an auditory cognitive assessment while being recorded with a single-channel EEG. Mini-Mental State Examination (MMSE) scores were used to designate groups, with cutoff scores of 24 and 27. EEG data processing included wavelet-packet decomposition and ML to extract EEG features. Data analysis included Pearson correlations and generalized linear mixed-models on several EEG variables: Delta and Theta frequency-bands and three ML-based EEG features: VC9, ST4, and A0, previously extracted from a different dataset and showed association with cognitive load.ResultsMMSE scores significantly correlated with reaction times and EEG features A0 and ST4. The features also showed significant separation between study groups: A0 separated between the MMSE < 24 and MMSE ≥ 28 groups, in addition to separating between young participants and senior groups. ST4 differentiated between the MMSE < 24 group and all other groups (MMSE 24–27, MMSE ≥ 28 and healthy young groups), showing sensitivity to subtle changes in cognitive states. EEG features Theta, Delta, A0, and VC9 showed increased activity with higher cognitive load levels, present only in the healthy young group, indicating different activity patterns between young and senior participants in different cognitive states. Consisted with previous reports, this association was most prominent for VC9 which significantly separated between all level of cognitive load.DiscussionThis study successfully demonstrated the ability to assess cognitive states with an easy-to-use single-channel EEG using an auditory cognitive assessment. The short set-up time and novel ML features enable objective and easy assessment of cognitive states. Future studies should explore the potential usefulness of this tool for characterizing changes in EEG patterns of cognitive decline over time, for detection of cognitive decline on a large scale in every clinic to potentially allow early intervention.Trial RegistrationNIH Clinical Trials Registry [https://clinicaltrials.gov/ct2/show/results/NCT04386902], identifier [NCT04386902]; Israeli Ministry of Health registry [https://my.health.gov.il/CliniTrials/Pages/MOH_2019-10-07_007352.aspx], identifier [007352].
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