Nature Communications (Oct 2020)

Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

  • Vasiliki Panagiotakopoulou,
  • Dina Ivanyuk,
  • Silvia De Cicco,
  • Wadood Haq,
  • Aleksandra Arsić,
  • Cong Yu,
  • Daria Messelodi,
  • Marvin Oldrati,
  • David C. Schöndorf,
  • Maria-Jose Perez,
  • Ruggiero Pio Cassatella,
  • Meike Jakobi,
  • Nicole Schneiderhan-Marra,
  • Thomas Gasser,
  • Ivana Nikić-Spiegel,
  • Michela Deleidi

DOI
https://doi.org/10.1038/s41467-020-18755-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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IFN-γ signalling is linked to regional neuronal vulnerability in Parkinson’s disease. The authors show that a PD-associated pathogenic LRRK2 missense mutation increases neuronal susceptibility to immune challenges via negative regulation of AKT phosphorylation and NFAT activation in human iPSC-derived neurons and microglia.