Nature Communications (Feb 2016)

GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway

  • Pablo D. Cárdenas,
  • Prashant D. Sonawane,
  • Jacob Pollier,
  • Robin Vanden Bossche,
  • Veena Dewangan,
  • Efrat Weithorn,
  • Lior Tal,
  • Sagit Meir,
  • Ilana Rogachev,
  • Sergey Malitsky,
  • Ashok P. Giri,
  • Alain Goossens,
  • Saul Burdman,
  • Asaph Aharoni

DOI
https://doi.org/10.1038/ncomms10654
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

Read online

Steroidal glycoalkaloids (SGAs) accumulate in solanaceous plants and contribute to plant defence but are toxic to humans. Here the authors show that the GAME9 transcription factor is a regulator of the SGA biosynthetic pathways providing a potential way to manipulate SGA levels in crops.