Nature Communications (Jan 2020)
YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
- Sung Yong Choi,
- Hosung Bae,
- Sun-Hye Jeong,
- Intae Park,
- Hyunsoo Cho,
- Seon Pyo Hong,
- Da-Hye Lee,
- Choong-kun Lee,
- Jin-Sung Park,
- Sang Heon Suh,
- Jeongwoon Choi,
- Myung Jin Yang,
- Jeon Yeob Jang,
- Lucas Onder,
- Jeong Hwan Moon,
- Han-Sin Jeong,
- Ralf H. Adams,
- Jin-Man Kim,
- Burkhard Ludewig,
- Joo-Hye Song,
- Dae-Sik Lim,
- Gou Young Koh
Affiliations
- Sung Yong Choi
- Center for Vascular Research, Institute for Basic Science (IBS)
- Hosung Bae
- Biomedical Science and Engineering Interdisciplinary Program, KAIST
- Sun-Hye Jeong
- Department of Biological Science, KAIST
- Intae Park
- Center for Vascular Research, Institute for Basic Science (IBS)
- Hyunsoo Cho
- Center for Vascular Research, Institute for Basic Science (IBS)
- Seon Pyo Hong
- Center for Vascular Research, Institute for Basic Science (IBS)
- Da-Hye Lee
- Department of Biological Science, KAIST
- Choong-kun Lee
- Center for Vascular Research, Institute for Basic Science (IBS)
- Jin-Sung Park
- Center for Vascular Research, Institute for Basic Science (IBS)
- Sang Heon Suh
- Center for Vascular Research, Institute for Basic Science (IBS)
- Jeongwoon Choi
- Center for Vascular Research, Institute for Basic Science (IBS)
- Myung Jin Yang
- Center for Vascular Research, Institute for Basic Science (IBS)
- Jeon Yeob Jang
- Department of Otorhinolaryngology, Ajou University School of Medicine
- Lucas Onder
- Institute of Immunobiology, Kantossipital St. Gallen
- Jeong Hwan Moon
- Department of Otorhinolaryngology - Head and Neck Surgery, Dankook University College of Medicine
- Han-Sin Jeong
- Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Ralf H. Adams
- Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster
- Jin-Man Kim
- Department of Pathology, Chungnam National University School of Medicine
- Burkhard Ludewig
- Institute of Immunobiology, Kantossipital St. Gallen
- Joo-Hye Song
- Center for Vascular Research, Institute for Basic Science (IBS)
- Dae-Sik Lim
- Department of Biological Science, KAIST
- Gou Young Koh
- Center for Vascular Research, Institute for Basic Science (IBS)
- DOI
- https://doi.org/10.1038/s41467-020-14293-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC differentiation, while hyperactivation of YAZ/TAZ inducing myofibroblastic FRCs and LN fibrosis.
