Association between BDNF rs6265 polymorphisms and postoperative cognitive dysfunction in Chinese Han Population

Abstract

Abstract Introduction Brain‐derived neurotrophic factor (BDNF) plays a critical role in the pathogenesis of postoperative cognitive dysfunction (POCD). In present study, we aimed to assess the possible association between POCD and BDNF rs6265 polymorphisms. Methods 124 patients aged 60 years or older scheduled for elective surgery under general anesthesia and 25 age‐ and gender‐matched healthy volunteers were recruited. POCD was identified using a neuropsychological test battery administered preoperatively, 7 days, and 3 months after surgery. Genotyping of rs6265 was performed using polymerase chain reaction amplification and restriction fragment length polymorphism analysis. Results 99 patients and 25 healthy controls were finally enrolled in the analysis. 29(29.3%) and 18(18.2%) of 99 patients had POCD at 7 days and 3 months after surgery, respectively. The patients carrying a G allele at the rs6265 locus showed a lower risk for POCD than an A allele carriers on postoperative 7 days, but not 3 months after surgery (OR = 0.67; 95% CI: 0.47–0.96; p = .017; OR = 0.69; 95% CI: 0.42–1.13; p = .14, respectively). The risk of POCD at 7 days following surgery was significantly lower in additive model (OR = 0.41; 95% CI: 0.2–0.84; p = .015) and dominant model (OR = 0.35; 95% CI: 0.13–0.96; p = .042). Conclusion We tentatively demonstrate that BDNF rs6265 polymorphisms might be associated with occurrence of POCD at 7 days after surgery and the A > G mutant at the rs6265 locus be likely a protective factor for early POCD in Chinese Han population.

Keywords

• BDNF
• cognition
• genotype
• polymorphism
• single nucleotide