Frontiers in Cellular Neuroscience (Jul 2022)
The Role of Genetic Variants in the Susceptibility of Noise-Induced Hearing Loss
- Xue-min Chen,
- Xue-min Chen,
- Xue-min Chen,
- Xue-min Chen,
- Xue-min Chen,
- Xin-miao Xue,
- Xin-miao Xue,
- Xin-miao Xue,
- Xin-miao Xue,
- Xin-miao Xue,
- Ning Yu,
- Ning Yu,
- Ning Yu,
- Ning Yu,
- Wei-wei Guo,
- Wei-wei Guo,
- Wei-wei Guo,
- Wei-wei Guo,
- Shuo-long Yuan,
- Shuo-long Yuan,
- Shuo-long Yuan,
- Shuo-long Yuan,
- Qing-qing Jiang,
- Qing-qing Jiang,
- Qing-qing Jiang,
- Qing-qing Jiang,
- Shi-ming Yang,
- Shi-ming Yang,
- Shi-ming Yang,
- Shi-ming Yang
Affiliations
- Xue-min Chen
- Medical School of Chinese PLA, Beijing, China
- Xue-min Chen
- Senior Department of Otolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing, China
- Xue-min Chen
- National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
- Xue-min Chen
- State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Xue-min Chen
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Xin-miao Xue
- Medical School of Chinese PLA, Beijing, China
- Xin-miao Xue
- Senior Department of Otolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing, China
- Xin-miao Xue
- National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
- Xin-miao Xue
- State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Xin-miao Xue
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Ning Yu
- Senior Department of Otolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing, China
- Ning Yu
- National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
- Ning Yu
- State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Ning Yu
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Wei-wei Guo
- Senior Department of Otolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing, China
- Wei-wei Guo
- National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
- Wei-wei Guo
- State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Wei-wei Guo
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Shuo-long Yuan
- Senior Department of Otolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing, China
- Shuo-long Yuan
- National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
- Shuo-long Yuan
- State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Shuo-long Yuan
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Qing-qing Jiang
- Senior Department of Otolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing, China
- Qing-qing Jiang
- National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
- Qing-qing Jiang
- State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Qing-qing Jiang
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- Shi-ming Yang
- Senior Department of Otolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing, China
- Shi-ming Yang
- National Clinical Research Center for Otolaryngologic Diseases, Beijing, China
- Shi-ming Yang
- State Key Lab of Hearing Science, Ministry of Education, Beijing, China
- Shi-ming Yang
- Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China
- DOI
- https://doi.org/10.3389/fncel.2022.946206
- Journal volume & issue
-
Vol. 16
Abstract
Noised-induced hearing loss (NIHL) is an acquired, progressive neurological damage caused by exposure to intense noise in various environments including industrial, military and entertaining settings. The prevalence of NIHL is much higher than other occupational injuries in industrialized countries. Recent studies have revealed that genetic factors, together with environmental conditions, also contribute to NIHL. A group of genes which are linked to the susceptibility of NIHL had been uncovered, involving the progression of oxidative stress, potassium ion cycling, cilia structure, heat shock protein 70 (HSP70), DNA damage repair, apoptosis, and some other genes. In this review, we briefly summarized the studies primary in population and some animal researches concerning the susceptible genes of NIHL, intending to give insights into the further exploration of NIHL prevention and individual treatment.
Keywords
