TREATMENT OF EPILEPSY WITH PROLONGED VALPROIC ACID FORMULATIONS IN OUT-PATIENT SETTINGS

Abstract

Therapeutic efficacy, adverse events, and patient-reported general well-being estimates were evaluated in patients with partial epilepsy treated with generics, Encorate Chrono and Valparin XR, given either as start-up therapy or following a forced switch to these drugs from the original valproic acid formulation. The evaluated drugs were administered as start-up therapy in 82 patients, and 67 study subjects were switched to these drugs from the original one. It was demonstrated that Encorate Chrono and Valparin XR are good choices for the treatment of epilepsy in the absence of the original drug; clinical electroencephalographic and laboratory monitoring should be established in such patients

Keywords

• epilepsy
• pharmacotherapy
• valproates
• generics
• valparin xr
• encorate chrono