Проблемы особо опасных инфекций (Jun 2015)

Peculiarities of Genome Structure of Toxigenic Vibrio cholerae El Tor Inaba Strain, Isolated from a Surface Water Body in the Territory of Rostov-on-Don in 2014

  • R. V. Pisanov,
  • M. I. Ezhova,
  • E. V. Monakhova,
  • A. V. Cherkasov,
  • Ya. M. Krasnov,
  • A. S. Vodop’Yanov,
  • T. A. Kul’Shan’,
  • L. F. Livanova,
  • S. A. Portenko,
  • A. S. Abdrashitova,
  • V. D. Kruglikov,
  • S. V. Titova

DOI
https://doi.org/10.21055/0370-1069-2015-2-63-67
Journal volume & issue
Vol. 0, no. 2
pp. 63 – 67

Abstract

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Carried out has been whole-genome sequencing of the Vibrio cholerae 81 El Tor Inaba strain DNA, isolated from Temernik River waters in the territory of Rostov-on-Don in July, 2014. Identified is the presence of hybrid CTX prophage, which contains ctxB gene of the classical type ( ctxB1 allele), as well as rstR gene El Tor type, tcpA gene with the mutations in coding and promoter regions ( tcpETCIRS allele), the null-mutation in rtxA gene, and extended deletion inside the pandemicity island VSP-II. All the stated above peculiarities are characteristic of cholera vibrio genovariants, which have an enhanced epidemic potential and have recently replaced the typical strains of this biovar.

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