The Role of MicroRNAs in Diabetic Nephropathy

Hao Wu; Lili Kong; Shanshan Zhou; Wenpeng Cui; Feng Xu; Manyu Luo; Xiangqi Li; Yi Tan; Lining Miao

doi:10.1155/2014/920134

Journal of Diabetes Research (Jan 2014)

The Role of MicroRNAs in Diabetic Nephropathy

Hao Wu,
Lili Kong,
Shanshan Zhou,
Wenpeng Cui,
Feng Xu,
Manyu Luo,
Xiangqi Li,
Yi Tan,
Lining Miao

Affiliations

Hao Wu: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
Lili Kong: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
Shanshan Zhou: Kosair Children’s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Wenpeng Cui: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
Feng Xu: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
Manyu Luo: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China
Xiangqi Li: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China
Yi Tan: Chinese-American Research Institute for Diabetic Complications at Wenzhou Medical University, Wenzhou 325035, China
Lining Miao: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China

DOI: https://doi.org/10.1155/2014/920134
Journal volume & issue: Vol. 2014

Abstract

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Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.

Published in Journal of Diabetes Research

ISSN: 2314-6745 (Print); 2314-6753 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.hindawi.com/journals/jdr/

About the journal