Nature Communications (Jun 2019)
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
- Moritz F. Eissmann,
- Christine Dijkstra,
- Andrew Jarnicki,
- Toby Phesse,
- Jamina Brunnberg,
- Ashleigh R. Poh,
- Nima Etemadi,
- Evelyn Tsantikos,
- Stefan Thiem,
- Nicholas D. Huntington,
- Margaret L. Hibbs,
- Alex Boussioutas,
- Michele A. Grimbaldeston,
- Michael Buchert,
- Robert J. J. O’Donoghue,
- Frederick Masson,
- Matthias Ernst
Affiliations
- Moritz F. Eissmann
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Christine Dijkstra
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Andrew Jarnicki
- Department of Pharmacology and Therapeutics, University of Melbourne
- Toby Phesse
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Jamina Brunnberg
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Ashleigh R. Poh
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Nima Etemadi
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Evelyn Tsantikos
- Department of Immunology and Pathology, Monash University
- Stefan Thiem
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Nicholas D. Huntington
- Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne
- Margaret L. Hibbs
- Department of Immunology and Pathology, Monash University
- Alex Boussioutas
- Department of Medicine, University of Melbourne
- Michele A. Grimbaldeston
- Centre for Cancer Biology, University of South Australia and SA Pathology
- Michael Buchert
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Robert J. J. O’Donoghue
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Frederick Masson
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- Matthias Ernst
- Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University
- DOI
- https://doi.org/10.1038/s41467-019-10676-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumors.
