Nature Communications (Dec 2017)
H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1
- Renata Z. Jurkowska,
- Su Qin,
- Goran Kungulovski,
- Wolfram Tempel,
- Yanli Liu,
- Pavel Bashtrykov,
- Judith Stiefelmaier,
- Tomasz P. Jurkowski,
- Srikanth Kudithipudi,
- Sara Weirich,
- Raluca Tamas,
- Hong Wu,
- Ludmila Dombrovski,
- Peter Loppnau,
- Richard Reinhardt,
- Jinrong Min,
- Albert Jeltsch
Affiliations
- Renata Z. Jurkowska
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- Su Qin
- Structural Genomics Consortium, University of Toronto
- Goran Kungulovski
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- Wolfram Tempel
- Structural Genomics Consortium, University of Toronto
- Yanli Liu
- Structural Genomics Consortium, University of Toronto
- Pavel Bashtrykov
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- Judith Stiefelmaier
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- Tomasz P. Jurkowski
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- Srikanth Kudithipudi
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- Sara Weirich
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- Raluca Tamas
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- Hong Wu
- Structural Genomics Consortium, University of Toronto
- Ludmila Dombrovski
- Structural Genomics Consortium, University of Toronto
- Peter Loppnau
- Structural Genomics Consortium, University of Toronto
- Richard Reinhardt
- Max-Planck-Genomzentrum Köln
- Jinrong Min
- Structural Genomics Consortium, University of Toronto
- Albert Jeltsch
- Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart University
- DOI
- https://doi.org/10.1038/s41467-017-02259-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
SETDB1 is a histone methyltransferase that generates H3K9me3 marks in euchromatic regions. Here the authors show that the triple Tudor domain (3TD) of SETDB1 binds histone H3 tails containing K14 acetylation combined with K9 methylation, and that the K9me–K14ac modification defines a novel chromatin state enriched at SETDB1 binding sites.
