Nature Communications (Nov 2018)
Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila
- Seung Kyu Lee,
- Yutong Xue,
- Weiping Shen,
- Yongqing Zhang,
- Yuyoung Joo,
- Muzammil Ahmad,
- Madoka Chinen,
- Yi Ding,
- Wai Lim Ku,
- Supriyo De,
- Elin Lehrmann,
- Kevin G. Becker,
- Elissa P. Lei,
- Keji Zhao,
- Sige Zou,
- Alexei Sharov,
- Weidong Wang
Affiliations
- Seung Kyu Lee
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Yutong Xue
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Weiping Shen
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Yongqing Zhang
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Yuyoung Joo
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Muzammil Ahmad
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Madoka Chinen
- Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive Kidney Diseases
- Yi Ding
- System Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health
- Wai Lim Ku
- System Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health
- Supriyo De
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Elin Lehrmann
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Kevin G. Becker
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Elissa P. Lei
- Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive Kidney Diseases
- Keji Zhao
- System Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health
- Sige Zou
- Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Alexei Sharov
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Weidong Wang
- Lab of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-018-07101-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced silencing complex (RISC) to promote heterochromatin formation and transcriptional silencing.
