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Disease Models & Mechanisms
(Jul 2024)
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome
Tara A. Gleeson,
Christina Kaiser,
Catherine B. Lawrence,
David Brough,
Stuart M. Allan,
Jack P. Green
Affiliations
Tara A. Gleeson
Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
Christina Kaiser
Swedish Orphan Biovitrum (Sobi), AB, Stockholm 112 76, Sweden
Catherine B. Lawrence
Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
David Brough
Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
Stuart M. Allan
Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
Jack P. Green
Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
DOI
https://doi.org/10.1242/dmm.050762
Journal volume & issue
Vol. 17, no. 7
Abstract
Read online
No abstracts available.
Keywords
cytokine storm syndrome
hyperinflammation
il-18
inflammasome
nlrp3
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