The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome

• Tara A. Gleeson,
• Christina Kaiser,
• Catherine B. Lawrence,
• David Brough,
• Stuart M. Allan,
• Jack P. Green

Affiliations

Tara A. Gleeson

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK

Christina Kaiser

Swedish Orphan Biovitrum (Sobi), AB, Stockholm 112 76, Sweden

Catherine B. Lawrence

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK

David Brough

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK

Stuart M. Allan

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK

Jack P. Green

Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK