Nature Communications (Apr 2018)
Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
- Li Chen,
- Liu Yang,
- Ling Yao,
- Xia-Ying Kuang,
- Wen-Jia Zuo,
- Shan Li,
- Feng Qiao,
- Yi-Rong Liu,
- Zhi-Gang Cao,
- Shu-Ling Zhou,
- Xiao-Yan Zhou,
- Wen-Tao Yang,
- Jin-Xiu Shi,
- Wei Huang,
- Xin Hu,
- Zhi-Ming Shao
Affiliations
- Li Chen
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Liu Yang
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Ling Yao
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Xia-Ying Kuang
- Department of Breast Surgery, The First Affiliated Hospital, Sun Yat-Sen University
- Wen-Jia Zuo
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Shan Li
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Feng Qiao
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Yi-Rong Liu
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Zhi-Gang Cao
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Shu-Ling Zhou
- Department of Oncology, Shanghai Medical College, Fudan University
- Xiao-Yan Zhou
- Department of Oncology, Shanghai Medical College, Fudan University
- Wen-Tao Yang
- Department of Oncology, Shanghai Medical College, Fudan University
- Jin-Xiu Shi
- Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI)
- Wei Huang
- Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI)
- Xin Hu
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- Zhi-Ming Shao
- Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-03867-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
The PI3K pathway is altered across various cancer types. Here the authors use amplicon exon sequencing to analyze the landscape of somatic mutations affecting the PI3K pathway specifically in breast cancer patients in China.
