Host-Guest Interaction of Cucurbit[8]uril with N-(3-Aminopropyl)cyclohexylamine: Cyclohexyl Encapsulation Triggered Ternary Complex

Yu Xia; Chuan-Zeng Wang; Mengkui Tian; Zhu Tao; Xin-Long Ni; Timothy J. Prior; Carl Redshaw

doi:10.3390/molecules23010175

Molecules (Jan 2018)

Host-Guest Interaction of Cucurbit[8]uril with N-(3-Aminopropyl)cyclohexylamine: Cyclohexyl Encapsulation Triggered Ternary Complex

Yu Xia,
Chuan-Zeng Wang,
Mengkui Tian,
Zhu Tao,
Xin-Long Ni,
Timothy J. Prior,
Carl Redshaw

Affiliations

Yu Xia: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Chuan-Zeng Wang: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Mengkui Tian: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Zhu Tao: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Xin-Long Ni: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Timothy J. Prior: Department of Chemistry, School of Mathematics and Physical Sciences, University of Hull, Hull HU6 7RX, UK
Carl Redshaw: Department of Chemistry, School of Mathematics and Physical Sciences, University of Hull, Hull HU6 7RX, UK

DOI: https://doi.org/10.3390/molecules23010175
Journal volume & issue: Vol. 23, no. 1
p. 175

Abstract

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The host-guest interaction of a series of cyclohexyl-appended guests with cucurbit[8]uril (Q[8]) was studied by 1H NMR spectroscopy, isothermal titration calorimetry (ITC), and X-ray crystallography. The X-ray structure revealed that two cycloalkane moieties can be simultaneously encapsulated in the hydrophobic cavity of the Q[8] host to form a ternary complex for the first time.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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