Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

Gulim K. Mukusheva; Roza I. Jalmakhanbetova; Altynay Zh. Shaibek; Manshuk S. Nurmaganbetova; Aigerym R. Zhasymbekova; Oralgazy A. Nurkenov; Ekaterina A. Akishina; Irina A. Kolesnik; Evgenij A. Dikusar; Tatiana I. Terpinskaya; Vladimir A. Kulchitsky; Vladimir I. Potkin; Alexander L. Pushkarchuk; Dmitry A. Lyakhov; Dominik L. Michels

doi:10.3390/molecules29143246

Molecules (Jul 2024)

Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

Gulim K. Mukusheva,
Roza I. Jalmakhanbetova,
Altynay Zh. Shaibek,
Manshuk S. Nurmaganbetova,
Aigerym R. Zhasymbekova,
Oralgazy A. Nurkenov,
Ekaterina A. Akishina,
Irina A. Kolesnik,
Evgenij A. Dikusar,
Tatiana I. Terpinskaya,
Vladimir A. Kulchitsky,
Vladimir I. Potkin,
Alexander L. Pushkarchuk,
Dmitry A. Lyakhov,
Dominik L. Michels

Affiliations

Gulim K. Mukusheva: Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan
Roza I. Jalmakhanbetova: Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan
Altynay Zh. Shaibek: Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan
Manshuk S. Nurmaganbetova: Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan
Aigerym R. Zhasymbekova: Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan
Oralgazy A. Nurkenov: Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan
Ekaterina A. Akishina: Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
Irina A. Kolesnik: Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
Evgenij A. Dikusar: Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
Tatiana I. Terpinskaya: Institute of Physiology, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
Vladimir A. Kulchitsky: Institute of Physiology, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
Vladimir I. Potkin: Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
Alexander L. Pushkarchuk: Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus
Dmitry A. Lyakhov: Computer, Electrical and Mathematical Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
Dominik L. Michels: Computer, Electrical and Mathematical Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia

DOI: https://doi.org/10.3390/molecules29143246
Journal volume & issue: Vol. 29, no. 14
p. 3246

Abstract

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Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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