Frontiers in Oncology (Apr 2023)

Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes

  • Elena Demuru,
  • Silvia Rossi,
  • Leonardo Ventura,
  • Luigino Dal Maso,
  • Stefano Guzzinati,
  • Alexander Katalinic,
  • Sebastien Lamy,
  • Valerie Jooste,
  • Corrado Di Benedetto,
  • Roberta De Angelis,
  • the EUROCARE-6 Working Group,
  • M. Hackl,
  • E. Van Eycken,
  • N. Van Damme,
  • Z. Valerianova,
  • M. Sekerija,
  • V. Scoutellas,
  • A. Demetriou,
  • L. Dušek,
  • D. Krejici,
  • H. Storm,
  • M. Mägi,
  • K. Innos,
  • N. Malila,
  • J. Pitkäniemi,
  • M. Velten,
  • X. Troussard,
  • A.M. Bouvier,
  • V. Jooste,
  • A.V. Guizard,
  • S. Dabakuyo Yonli,
  • M. Maynadié,
  • J.B. Nousbaum,
  • G. Coureau,
  • A. Monnereau,
  • I. Baldi,
  • K. Hammas,
  • B. Tretarre,
  • M. Colonna,
  • S. Plouvier,
  • T. D’Almeida,
  • F. Molinié,
  • A. Cowppli-Bony,
  • S. Bara,
  • G. Defossez,
  • B. LapÔtre-Ledoux,
  • P. Grosclaude,
  • L. Daubisse-Marliac,
  • S. Luttmann,
  • R. Stabenow,
  • A. Nennecke,
  • J. Kieschke,
  • S. Zeissig,
  • B. Holleczek,
  • A. Katalinic,
  • H. Birgisson,
  • D. Murray,
  • P.M. Walsh,
  • G. Mazzoleni,
  • F. Vittadello,
  • F. Cuccaro,
  • R. Galasso,
  • G. Sampietro,
  • S. Rosso,
  • C. Gasparotti,
  • G. Maifredi,
  • M. Ferrante,
  • R. Ragusa,
  • M.L. Gambino,
  • M. Lanzoni,
  • P. Ballotari,
  • E. Giacomazzi,
  • S. Ferretti,
  • A. Caldarella,
  • G. Manneschi,
  • G. Gatta,
  • M. Sant,
  • P. Baili,
  • F. Berrino,
  • L. Botta,
  • A. Trama,
  • R. Lillini,
  • A. Bernasconi,
  • L. Bonfarnuzzo,
  • C. Vener,
  • F. Didoné,
  • P. Lasalvia,
  • G. Del Monego,
  • L. Buratti,
  • G. Tagliabue,
  • D. Serraino,
  • L. Dal Maso,
  • R. Capocaccia,
  • R. De Angelis,
  • E. Demuru,
  • C. Di Benedetto,
  • S. Rossi,
  • M. Santaquilani,
  • S. Venanzi,
  • M. Tallon,
  • L. Boni,
  • S. Iacovacci,
  • V. Gennaro,
  • A.G. Russo,
  • F. Gervasi,
  • G. Spagnoli,
  • L. Cavalieri d’’Oro,
  • M. Fusco,
  • M.F. Vitale,
  • M. Usala,
  • W. Mazzucco,
  • M. Michiara,
  • G. Chiranda,
  • G. Cascone,
  • C.P. Rollo,
  • L. Mangone,
  • F. Falcini,
  • R. Cavallo,
  • D. Piras,
  • A. Madeddu,
  • F. Bella,
  • A.C. Fanetti,
  • S. Minerba,
  • G. Candela,
  • T. Scuderi,
  • R.V. Rizzello,
  • M. Rugge,
  • A. Brustolin,
  • S. Pildava,
  • G. Smailyte,
  • M. Azzopardi,
  • T.B. Johannesen,
  • J. Didkowska,
  • U. Wojciechowska,
  • M. Bielska-Lasota,
  • A. Pais,
  • J. Rodrigues,
  • M.J. Bento,
  • A. Miranda,
  • V. Zadnik,
  • T. Zagar,
  • C. Sánchez-Contador Escudero,
  • P. Franch Sureda,
  • A. Lopez de Munain,
  • M. De-La-Cruz,
  • M.D. Rojas,
  • A. Aleman,
  • A. Vizcaino,
  • R. Marcos-Gragera,
  • A. Sanvisens,
  • M.J. Sanchez,
  • M.D. Chirlaque,
  • A. Sanchez-Gil,
  • M. Guevara,
  • E. Ardanaz,
  • A. Ameijide,
  • C. Carulla,
  • Y. Bergeron,
  • C. Bouchardy,
  • S. Mohsen Mousavi,
  • P. Went,
  • M. Blum,
  • A. Bordoni,
  • O. Visser,
  • S. Stevens,
  • J. Broggio,
  • A. Gavin,
  • D. Morrison,
  • D.W. Huws

DOI
https://doi.org/10.3389/fonc.2023.1114701
Journal volume & issue
Vol. 13

Abstract

Read online

IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from US-SEER cancer registries. Relying on the EUROCARE-6 study dataset we compare standard vs alternative complete prevalence estimates using data from 62 registries in 27 countries by sex, cancer type and registration time.ResultsFor tumours mostly diagnosed in the elderly the empirical estimates differ little from standard estimates (on average less than 5% after 10-15 years of registration), especially for low prognosis cancers. For early-onset cancers (bone, brain, cervix uteri, testis, Hodgkin disease, soft tissues) the empirical method may produce substantial underestimations of complete prevalence (up to 20%) even when based on 35-year observations. SEER estimates are comparable to the standard ones for most cancers, including many early-onset tumours, even when derived from short time series (10-15 years). Longer observations are however needed when cancer-specific incidence and prognosis differ remarkably between US and European populations (endometrium, thyroid or stomach).DiscussionThese results may facilitate the dissemination of complete prevalence estimates across Europe and help bridge the current information gaps.

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