Nature Communications (Dec 2018)

IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses

  • Olga Babaev,
  • Hugo Cruces-Solis,
  • Carolina Piletti Chatain,
  • Matthieu Hammer,
  • Sally Wenger,
  • Heba Ali,
  • Nikolaos Karalis,
  • Livia de Hoz,
  • Oliver M. Schlüter,
  • Yuchio Yanagawa,
  • Hannelore Ehrenreich,
  • Holger Taschenberger,
  • Nils Brose,
  • Dilja Krueger-Burg

DOI
https://doi.org/10.1038/s41467-018-07762-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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IgSF9b is a synaptic adhesion protein that has been linked to psychiatric disorders. Here the authors show that deletion of IgSF9b regulates anxiety-like behaviour in mice by increasing inhibitory synaptic transmission in the centromedial amygdala.