Alterations in the neural correlates of affective inhibitory control following cognitive behavioral therapy for depression: A Canadian biomarker integration network for depression (CAN-BIND) study

Prabhjot Dhami; Lena C. Quilty; Benjamin Schwartzmann; Rudolf Uher; Timothy A. Allen; Stefan Kloiber; Raymond W. Lam; Glenda MacQueen; Benicio N. Frey; Roumen Milev; Daniel J. Müller; Susan Rotzinger; Sidney H. Kennedy; Faranak Farzan

Journal of Affective Disorders Reports (Dec 2022)

Alterations in the neural correlates of affective inhibitory control following cognitive behavioral therapy for depression: A Canadian biomarker integration network for depression (CAN-BIND) study

Prabhjot Dhami,
Lena C. Quilty,
Benjamin Schwartzmann,
Rudolf Uher,
Timothy A. Allen,
Stefan Kloiber,
Raymond W. Lam,
Glenda MacQueen,
Benicio N. Frey,
Roumen Milev,
Daniel J. Müller,
Susan Rotzinger,
Sidney H. Kennedy,
Faranak Farzan

Affiliations

Prabhjot Dhami: School of Mechatronic Systems Engineering, eBrain Lab, Simon Fraser University, 250-13450 102 Avenue, Surrey, BC V3T 0A3, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
Lena C. Quilty: Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
Benjamin Schwartzmann: School of Mechatronic Systems Engineering, eBrain Lab, Simon Fraser University, 250-13450 102 Avenue, Surrey, BC V3T 0A3, Canada
Rudolf Uher: Dalhousie University, Halifax, NS, Canada
Timothy A. Allen: Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
Stefan Kloiber: Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
Raymond W. Lam: University of British Columbia, Vancouver, BC, Canada
Glenda MacQueen: University of Calgary, Calgary, AB, Canada
Benicio N. Frey: Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, ON, Canada
Roumen Milev: Queen's University, Kingston, ON, Canada
Daniel J. Müller: Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Susan Rotzinger: Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Unity Health Toronto, Toronto, ON, Canada
Sidney H. Kennedy: Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Unity Health Toronto, Toronto, ON, Canada
Faranak Farzan: School of Mechatronic Systems Engineering, eBrain Lab, Simon Fraser University, 250-13450 102 Avenue, Surrey, BC V3T 0A3, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Corresponding author at: School of Mechatronic Systems Engineering, eBrain Lab, Simon Fraser University, 250-13450 102 Avenue, Surrey, BC V3T 0A3, Canada.

Journal volume & issue: Vol. 10
p. 100413

Abstract

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Background: Cognitive behavioral therapy (CBT) is an efficacious treatment for depression. CBT may in part exert its therapeutic effect by strengthening inhibitory control (IC). However, the relationship between CBT and IC has yet to be thoroughly explored; in particular, it is not clear whether IC is modulated following a course of CBT. Methods: Forty-one adults with depression were recruited to undergo sixteen weeks of CBT; data from twenty-five healthy controls were used for baseline comparisons. Participants completed an affective Go/No-go task, a measure of IC, while undergoing electroencephalography recording. Electroencephalography measures of interest were the event-related potential (ERP) N2 and P3 components. Results: At baseline, individuals with depression exhibited greater ERP amplitudes during the N2 regardless of affective condition; source reconstruction attributed this to patients exhibiting greater activity in the superior frontal gyrus, right temporal lobe, and anterior cingulate cortex (ACC). Following treatment, the ERP amplitude during the N2 component decreased for angry stimuli but increased for happy stimuli. Source reconstruction attributed ERP changes in the angry-condition to the left occipital and fusiform gyrus, and changes in the happy-condition to regions including the superior frontal gyrus and ACC. Limitations: There was no placebo-treatment group. Conclusions: Neural correlates of the affective Go/No-go task were altered in depression and were found to be selectively modulated over the course of CBT in a condition- and region-specific manner. These findings support the notion that the modulation of IC may be one of the potential therapeutic mechanisms of CBT in the treatment of depression.

Published in Journal of Affective Disorders Reports

ISSN: 2666-9153 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Other systems of medicine: Mental healing
Website: https://www.journals.elsevier.com/journal-of-affective-disorders-reports

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