Emerging Infectious Diseases (Dec 2020)

Sensitive Detection of SARS-CoV-2–Specific Antibodies in Dried Blood Spot Samples

  • Gabriella L. Morley,
  • Stephen Taylor,
  • Sian Jossi,
  • Marisol Perez-Toledo,
  • Sian E. Faustini,
  • Edith Marcial-Juarez,
  • Adrian M. Shields,
  • Margaret Goodall,
  • Joel D. Allen,
  • Yasunori Watanabe,
  • Maddy L. Newby,
  • Max Crispin,
  • Mark T. Drayson,
  • Adam F. Cunningham,
  • Alex G. Richter,
  • Matthew K. O’Shea

DOI
https://doi.org/10.3201/eid2612.203309
Journal volume & issue
Vol. 26, no. 12
pp. 2970 – 2973

Abstract

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Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.

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