Nature Communications (Jan 2022)
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology
- Zoeb Jiwaji,
- Sachin S. Tiwari,
- Rolando X. Avilés-Reyes,
- Monique Hooley,
- David Hampton,
- Megan Torvell,
- Delinda A. Johnson,
- Jamie McQueen,
- Paul Baxter,
- Kayalvizhi Sabari-Sankar,
- Jing Qiu,
- Xin He,
- Jill Fowler,
- James Febery,
- Jenna Gregory,
- Jamie Rose,
- Jane Tulloch,
- Jamie Loan,
- David Story,
- Karina McDade,
- Amy M. Smith,
- Peta Greer,
- Matthew Ball,
- Peter C. Kind,
- Paul M. Matthews,
- Colin Smith,
- Owen Dando,
- Tara L. Spires-Jones,
- Jeffrey A. Johnson,
- Siddharthan Chandran,
- Giles E. Hardingham
Affiliations
- Zoeb Jiwaji
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Sachin S. Tiwari
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Rolando X. Avilés-Reyes
- Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison
- Monique Hooley
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- David Hampton
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Megan Torvell
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Delinda A. Johnson
- Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison
- Jamie McQueen
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Paul Baxter
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Kayalvizhi Sabari-Sankar
- Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison
- Jing Qiu
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Xin He
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Jill Fowler
- Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square
- James Febery
- Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square
- Jenna Gregory
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Jamie Rose
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Jane Tulloch
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Jamie Loan
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- David Story
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Karina McDade
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Amy M. Smith
- UK Dementia Research Institute at Imperial College, Burlington Danes Building, Hammersmith Hospital
- Peta Greer
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Matthew Ball
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Peter C. Kind
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Paul M. Matthews
- UK Dementia Research Institute at Imperial College, Burlington Danes Building, Hammersmith Hospital
- Colin Smith
- Centre for Clinical Brain Sciences, University of Edinburgh Chancellor’s Building
- Owen Dando
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Tara L. Spires-Jones
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Jeffrey A. Johnson
- Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison
- Siddharthan Chandran
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- Giles E. Hardingham
- UK Dementia Research Institute at the University of Edinburgh, Chancellor’s Building, Edinburgh Medical School
- DOI
- https://doi.org/10.1038/s41467-021-27702-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.
