Nature Communications (Jun 2020)
Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
- Yann W. Yap,
- Patricia M. Rusu,
- Andrea Y. Chan,
- Barbara C. Fam,
- Andreas Jungmann,
- Samantha M. Solon-Biet,
- Christopher K. Barlow,
- Darren J. Creek,
- Cheng Huang,
- Ralf B. Schittenhelm,
- Bruce Morgan,
- Dieter Schmoll,
- Bente Kiens,
- Matthew D. W. Piper,
- Mathias Heikenwälder,
- Stephen J. Simpson,
- Stefan Bröer,
- Sofianos Andrikopoulos,
- Oliver J. Müller,
- Adam J. Rose
Affiliations
- Yann W. Yap
- Department of Biochemistry and Molecular Biology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University
- Patricia M. Rusu
- Department of Biochemistry and Molecular Biology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University
- Andrea Y. Chan
- Department of Biochemistry and Molecular Biology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University
- Barbara C. Fam
- Department of Medicine (Austin Health), University of Melbourne
- Andreas Jungmann
- Department of Internal Medicine III, University Hospital Heidelberg
- Samantha M. Solon-Biet
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Christopher K. Barlow
- Biomedical Proteomics and Metabolomics Facility and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Darren J. Creek
- Biomedical Proteomics and Metabolomics Facility and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Cheng Huang
- Biomedical Proteomics and Metabolomics Facility and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Ralf B. Schittenhelm
- Biomedical Proteomics and Metabolomics Facility and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Bruce Morgan
- Institute for Biochemistry, Centre for Human and Molecular Biology (ZHMB), Saarland University
- Dieter Schmoll
- Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst
- Bente Kiens
- Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Matthew D. W. Piper
- School of Biological Sciences, School of Life and Environmental Sciences, Monash University
- Mathias Heikenwälder
- Division of Chronic Inflammation and Cancer, German Cancer Research Center
- Stephen J. Simpson
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Stefan Bröer
- Research School of Biology, Australian National University
- Sofianos Andrikopoulos
- Department of Medicine (Austin Health), University of Melbourne
- Oliver J. Müller
- German Center for Cardiovascular Research (DZHK)
- Adam J. Rose
- Department of Biochemistry and Molecular Biology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University
- DOI
- https://doi.org/10.1038/s41467-020-16568-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Dietary protein dilution, where protein is reduced and replaced by other nutrient sources without caloric restriction, promotes metabolic health via the hepatokine Fgf21. Here, the authors show that essential amino acids threonine and tryptophan are necessary and sufficient to induce these effects.
