CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis

Kaiyu Xu; Ying Zhang; Wandi Xiong; Zhongyu Zhang; Zhengbo Wang; Longbao Lv; Chao Liu; Zhengfei Hu; Yong-Tang Zheng; Lin Lu; Xin-Tian Hu; Jiali Li

doi:10.1038/s41467-020-17435-7

Nature Communications (Jul 2020)

CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis

Kaiyu Xu,
Ying Zhang,
Wandi Xiong,
Zhongyu Zhang,
Zhengbo Wang,
Longbao Lv,
Chao Liu,
Zhengfei Hu,
Yong-Tang Zheng,
Lin Lu,
Xin-Tian Hu,
Jiali Li

Affiliations

Kaiyu Xu: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
Ying Zhang: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
Wandi Xiong: National Institute on Drug Dependence, Peking University
Zhongyu Zhang: National Institute on Drug Dependence, Peking University
Zhengbo Wang: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
Longbao Lv: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
Chao Liu: Kunming Primate Research Center of the Chinese Academy of Sciences
Zhengfei Hu: Kunming Primate Research Center of the Chinese Academy of Sciences
Yong-Tang Zheng: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
Lin Lu: National Institute on Drug Dependence, Peking University
Xin-Tian Hu: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
Jiali Li: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-17435-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Circular RNAs are expressed in the brain and show age-dependent expression patterns. Here the authors show the circGRIA1 is expressed in an age-dependent manner in the male macaque brain and serves a functional role in synaptic plasticity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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