‎Clinical and laboratory predictors of disease severity and outcome in ‎COVID 19 infected patients in Suez Canal University Hospital, single ‎center study from Egypt

Abstract

Background: The novel corona virus is a high contagious disease, ‎declared by World Health Organization (WHO) as a global pandemic in 2020 with profound ‎impact on morbidity and mortality, assessment of outcomes in infected patients and ‎knowledge of prediction of mortality and morbidity are important. We aimed to assess ‎the clinical and laboratory findings in predicting COVID-19 severity and outcome in ‎patients admitted to Suez Canal University Teaching Hospital.‎ Methodology: This cross-sectional prospective study included 500 ‎confirmed PCR COVID-19 infected patients, selected through random sampling‎. A ‎structured checklist was used to collect patient data.‎ Results: Mean age was 61.8 years, 56.2% were males, 74.8% had ‎comorbidities. Lung involvement was evident in more than 75% on CT, 17.2% had ‎leukopenia, 42.2% had lymphocytopenia between 5 – 10% and 93% of the patients ‎had elevated neutrophil- lymphocyte ratio. 65.8% had elevated D-dimer, and elevated ‎liver and kidney functions were found in 40.6% and 25% respectively. The mortality ‎rate in studied population was 30.2% and it was significantly associated with old age, ‎hypoxemia, having high involvement of the lungs on CT. Decreased WBC count, ‎high D-dimer level and high NLR associated with severity and increased death rate of ‎the disease.‎ Conclusion: The study revealed many findings with impact on the patient's severity and outcome old age, laboratory findings, CT imaging and need to antiviral therapy the most predicting factors of the ‎severity and prognosis of the patients.

Keywords

• covid-19
• predictors
• severity
• outcome
• egypt‎