Nature Communications (Sep 2018)

Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations

  • Jiang Chang,
  • Jianbo Tian,
  • Ying Zhu,
  • Rong Zhong,
  • Kan Zhai,
  • Jiaoyuan Li,
  • Juntao Ke,
  • QiangQiang Han,
  • Jiao Lou,
  • Wei Chen,
  • Beibei Zhu,
  • Na Shen,
  • Yi Zhang,
  • Yajie Gong,
  • Yang Yang,
  • Danyi Zou,
  • Xiating Peng,
  • Zhi Zhang,
  • Xuemei Zhang,
  • Kun Huang,
  • Ming Yang,
  • Li Wang,
  • Chen Wu,
  • Dongxin Lin,
  • Xiaoping Miao

DOI
https://doi.org/10.1038/s41467-018-06136-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

Read online

Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk.