CO2 Permeability of Biological Membranes and Role of CO2 Channels

Abstract

We summarize here, mainly for mammalian systems, the present knowledge of (a) the membrane CO2 permeabilities in various tissues; (b) the physiological significance of the value of the CO2 permeability; (c) the mechanisms by which membrane CO2 permeability is modulated; (d) the role of the intracellular diffusivity of CO2 for the quantitative significance of cell membrane CO2 permeability; (e) the available evidence for the existence of CO2 channels in mammalian and artificial systems, with a brief view on CO2 channels in fishes and plants; and, (f) the possible significance of CO2 channels in mammalian systems.

Keywords

• CO2 permeability
• membrane cholesterol
• protein CO2 channels
• aquaporins
• Rhesus proteins
• aquaporin-1-deficient mice