Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation

Simon Zenke; Mauricio P. Sica; Florian Steinberg; Julia Braun; Alicia Zink; Alina Gavrilov; Alexander Hilger; Aditya Arra; Monika Brunner-Weinzierl; Roland Elling; Niklas Beyersdorf; Tim Lämmermann; Cristian R. Smulski; Jan C. Rohr

doi:10.1038/s41467-022-34156-1

Nature Communications (Oct 2022)

Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation

Simon Zenke,
Mauricio P. Sica,
Florian Steinberg,
Julia Braun,
Alicia Zink,
Alina Gavrilov,
Alexander Hilger,
Aditya Arra,
Monika Brunner-Weinzierl,
Roland Elling,
Niklas Beyersdorf,
Tim Lämmermann,
Cristian R. Smulski,
Jan C. Rohr

Affiliations

Simon Zenke: Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-University
Mauricio P. Sica: Medical Physics Department, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Florian Steinberg: Center for Biological Systems Analysis, Albert-Ludwigs-University Freiburg
Julia Braun: Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-University
Alicia Zink: Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-University
Alina Gavrilov: Immune Cell Dynamics Group, Max Planck Institute of Immunobiology and Epigenetics
Alexander Hilger: Department of Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, Albert-Ludwigs-University
Aditya Arra: Department of Experimental Pediatrics and Neonatology and Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University
Monika Brunner-Weinzierl: Department of Experimental Pediatrics and Neonatology and Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University
Roland Elling: Department of Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, Albert-Ludwigs-University
Niklas Beyersdorf: Institute of Virology and Immunobiology, University of Würzburg
Tim Lämmermann: Immune Cell Dynamics Group, Max Planck Institute of Immunobiology and Epigenetics
Cristian R. Smulski: Medical Physics Department, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Jan C. Rohr: Institute of Immunodeficiency, Medical Center and Faculty of Medicine, Albert-Ludwigs-University

DOI: https://doi.org/10.1038/s41467-022-34156-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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A number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by CD28 or CTLA4 and link this to cellular control of costimulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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