Engineering the Modular Receptor-Binding Proteins of <i>Klebsiella</i> Phages Switches Their Capsule Serotype Specificity

Abstract

The antimicrobial resistance crisis has rekindled interest in bacteriophage therapy. Phages have been studied over a century as therapeutics to treat bacterial infections, but one of the biggest challenges for the use of phages in therapeutic interventions remains their high specificity.