Nature Communications (Jul 2020)
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
- M. C. Wilkes,
- K. Siva,
- J. Chen,
- G. Varetti,
- M. Y. Youn,
- H. Chae,
- F. Ek,
- R. Olsson,
- T. Lundbäck,
- D. P. Dever,
- T. Nishimura,
- A. Narla,
- B. Glader,
- H. Nakauchi,
- M. H. Porteus,
- C. E. Repellin,
- H. T. Gazda,
- S. Lin,
- M. Serrano,
- J. Flygare,
- K. M. Sakamoto
Affiliations
- M. C. Wilkes
- Division of Hematology/Oncology, Department of Pediatrics, Stanford University
- K. Siva
- Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University
- J. Chen
- Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University
- G. Varetti
- Institute for Research in Biomedicine (IRB Barcelona)
- M. Y. Youn
- Division of Hematology/Oncology, Department of Pediatrics, Stanford University
- H. Chae
- Division of Hematology/Oncology, Department of Pediatrics, Stanford University
- F. Ek
- Chemical Biology and Therapeutics Group, Department of Medical Science, Lund University
- R. Olsson
- Chemical Biology and Therapeutics Group, Department of Medical Science, Lund University
- T. Lundbäck
- Chemical Biology Consortium Sweden (CBCS), Science for Life Laboratory, Department for Medical Biochemistry and Biophysics, Karolinska Institutet
- D. P. Dever
- Department of Pediatrics, Stanford University
- T. Nishimura
- Department of Genetics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- A. Narla
- Division of Hematology/Oncology, Department of Pediatrics, Stanford University
- B. Glader
- Division of Hematology/Oncology, Department of Pediatrics, Stanford University
- H. Nakauchi
- Department of Genetics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- M. H. Porteus
- Department of Pediatrics, Stanford University
- C. E. Repellin
- Biosciences Division, SRI International
- H. T. Gazda
- Broad Institute of MIT and Harvard
- S. Lin
- Department of Molecular, Cell and Development Biology, University of California
- M. Serrano
- Institute for Research in Biomedicine (IRB Barcelona)
- J. Flygare
- Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University
- K. M. Sakamoto
- Division of Hematology/Oncology, Department of Pediatrics, Stanford University
- DOI
- https://doi.org/10.1038/s41467-020-17100-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome that is associated with anemia. Here, the authors examine the role of Nemo-like kinase (NLK) in erythroid cells in the pathogenesis of DBA and as a potential target for therapy.
