Медицинская иммунология (Jul 2014)

COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES

  • L. A. Ivanushko,
  • T. F. Solovyeva,
  • T. S. Zaporozhets,
  • P. A. Lukyanov,
  • V. I. Gorbach,
  • N. N. Besednova

DOI
https://doi.org/10.15789/1563-0625-2007-4-5-397-404
Journal volume & issue
Vol. 9, no. 4-5
pp. 397 – 404

Abstract

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Abstract. Comparative study was carried out, aiming to assess immunostimulatory properties of high-molecular chitosan (Ch-HM) and its derivatives, i.e., low molecular weight chitosan (Ch-LM), N-3-hydroxymyristoyl (Ch-LM) at a low acylation ratio, N-3-hydroxymyristoylchitooligosaccharides (N-acylchito-biose, -triose, -tetraose), N-, O-carboxyalkylchitosans (carboxymethyl, -ethyl, -propyl derivates). It was established, that the chemical modifications of chitosan influenced its biological activity. The derivatives of chitosan were found to have improved physical properties (good solubility in neutral and alkaline solutions, low viscosity in acidic solutions, good absorption from a gastrointestinal compartment), as compared with initial (high molecular weight) chitosan formula. They possess immunomodulatory properties and may be regarded as promising substances for preparation of medical drugs and biologically active food additives (BAFA).

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