Nature Communications (Jun 2021)
Restoration of the molecular clock is tumor suppressive in neuroblastoma
- Myrthala Moreno-Smith,
- Giorgio Milazzo,
- Ling Tao,
- Baharan Fekry,
- Bokai Zhu,
- Mahmoud A. Mohammad,
- Simone Di Giacomo,
- Roshan Borkar,
- Karthik Reddy Kami Reddy,
- Mario Capasso,
- Sanjeev A. Vasudevan,
- Pavel Sumazin,
- John Hicks,
- Nagireddy Putluri,
- Giovanni Perini,
- Kristin Eckel-Mahan,
- Thomas P. Burris,
- Eveline Barbieri
Affiliations
- Myrthala Moreno-Smith
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Giorgio Milazzo
- Department of Pharmacy and Biotechnology, University of Bologna
- Ling Tao
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- Baharan Fekry
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
- Bokai Zhu
- Department of Medicine, Division of Endocrinology and Metabolism, Aging Institute of UPMC, University of Pittsburgh School of Medicine
- Mahmoud A. Mohammad
- Department of Pediatrics, Children’s Nutrition Research Center, US Department of Agriculture, Agricultural Research Service, Baylor College of Medicine
- Simone Di Giacomo
- Department of Pharmacy and Biotechnology, University of Bologna
- Roshan Borkar
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Karthik Reddy Kami Reddy
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Mario Capasso
- Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli
- Sanjeev A. Vasudevan
- Division of Pediatric Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
- Pavel Sumazin
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- John Hicks
- Department of Pathology and Immunology, Baylor College of Medicine
- Nagireddy Putluri
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Giovanni Perini
- Department of Pharmacy and Biotechnology, University of Bologna
- Kristin Eckel-Mahan
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)
- Thomas P. Burris
- Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy
- Eveline Barbieri
- Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-24196-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neuroblastoma growth
