Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

Norbert Pardi; Anthony J. Secreto; Xiaochuan Shan; Fotini Debonera; Joshua Glover; Yanjie Yi; Hiromi Muramatsu; Houping Ni; Barbara L. Mui; Ying K. Tam; Farida Shaheen; Ronald G. Collman; Katalin Karikó; Gwenn A. Danet-Desnoyers; Thomas D. Madden; Michael J. Hope; Drew Weissman

doi:10.1038/ncomms14630

Nature Communications (Mar 2017)

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

Norbert Pardi,
Anthony J. Secreto,
Xiaochuan Shan,
Fotini Debonera,
Joshua Glover,
Yanjie Yi,
Hiromi Muramatsu,
Houping Ni,
Barbara L. Mui,
Ying K. Tam,
Farida Shaheen,
Ronald G. Collman,
Katalin Karikó,
Gwenn A. Danet-Desnoyers,
Thomas D. Madden,
Michael J. Hope,
Drew Weissman

Affiliations

Norbert Pardi: Department of Medicine, University of Pennsylvania
Anthony J. Secreto: Department of Medicine, University of Pennsylvania
Xiaochuan Shan: Department of Medicine, University of Pennsylvania
Fotini Debonera: Department of Medicine, University of Pennsylvania
Joshua Glover: Department of Medicine, University of Pennsylvania
Yanjie Yi: Department of Medicine, University of Pennsylvania
Hiromi Muramatsu: Department of Medicine, University of Pennsylvania
Houping Ni: Department of Medicine, University of Pennsylvania
Barbara L. Mui: Acuitas Therapeutics
Ying K. Tam: Acuitas Therapeutics
Farida Shaheen: Department of Medicine, University of Pennsylvania
Ronald G. Collman: Department of Medicine, University of Pennsylvania
Katalin Karikó: Department of Medicine, University of Pennsylvania
Gwenn A. Danet-Desnoyers: Department of Medicine, University of Pennsylvania
Thomas D. Madden: Acuitas Therapeutics
Michael J. Hope: Acuitas Therapeutics
Drew Weissman: Department of Medicine, University of Pennsylvania

DOI: https://doi.org/10.1038/ncomms14630
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Monoclonal antibodies are highly effective therapeutics that can be delivered as proteins or encoded DNA or mRNA. Here the authors develop lipid nanoparticle-formulated nucleoside-modified mRNA encoding an HIV-1 neutralizing antibody and see sustained and protective antibody levels in treated mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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