Endothelium depen dent factors of vasoconstriction (thromboxane B2) and vasodilation (6-prostaglandin F1α) in children with primary arterial hype rten sion

Abstract

Background: Vasoconstrictor and vasodilator substances imbalance play a major role in the formation of arterial hypertension. But the ratio between thromboxane B2 and 6-prostaglandin F1α in children with various forms of primary arterial hypertension (PAH) are insufficiently studied. Aim of the study: to explore the features of the content of thromboxane B2, 6-keto-PGF-1alfa and their correlation in children with different clinical and pathogenetic forms of PAH. Material and methods: The study involved 83 children aged 9 to 17 years. The first group included 32 children with stable PAH, the second – 32 children with labile PAH, the third (control group) – 21 children with normal blood pressure. TXB2 and 6-PGF1α serum levels were investigated by ELISA. All children were held ambulatory blood pressure monitoring (ABPM). Results: Average TXB2 levels in boys were 25,05 ±6,43 ng/ml at stable PAH and 27,26 ±11,26 ng/ml at labile PAH, which exceeded their levels in the control group (p < 0,05). Girls’ TXB2 level was elevated at labile PAH (to 11,06 ±1,79 ng/ml, p < 0,05) and did not differ from the control group at stable PAH. Girls’ 6-PGF1α level was up to 3,41 ±0,52 ng/ml at stable PAH and up to 2,63 ±0,25 ng/ml at labile PAH. Conclusions: Violation of the ratio between endothelial vasoconstriction (thromboxane) and vasodilatation (prostacyclin) factors in boys with PAH is due to increased TXB2 levels compared with children with normal blood pressure (p < 0,05). Girls with PAH have better compensatory vasodilation opportunities compared with boys according to increased prostacyclin production. That prevents the progression of endothelial dysfunction and PAH stabilization in girls.

Keywords

• thromboxane B2
• 6-prostaglandin F1α;children;primary arterial hypertension