Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Abstract

Background: Ulcerative colitis is acommontype of inflammatory bowel disease (IBD). The aim of the present study was to examinethe relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients withulcerative colitis.Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDAlevel were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlationcoefficient test. P < 0.05 was considered statistically significant.Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitisin comparison with the healthy controls (P < 0.05). No significant correlation was observed between theMDAlevel and triglyceride,cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed betweenHDL-C and MDA levels (r, -0.306; P < 0.05).Conclusions: The inverse correlation between HDL-C andMDAlevels can be regarded as an indicator of the protective role of HDL-Cagainst lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparisonwith healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.

Keywords

• ulcerative colitis disease
• hdl-c level
• mda level
• active and inactive disease