New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i>

Po-Yen Chen; Chih-Chao Chang; Hui-Chi Huang; Li-Jie Zhang; Chia-Ching Liaw; Yu-Chi Lin; Nham-Linh Nguyen; Thanh-Hoa Vo; Yung-Yi Cheng; Susan  L. Morris-Natschke; Kuo-Hsiung Lee; Yao-Haur Kuo

doi:10.3390/molecules24071375

Molecules (Apr 2019)

New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i>

Po-Yen Chen,
Chih-Chao Chang,
Hui-Chi Huang,
Li-Jie Zhang,
Chia-Ching Liaw,
Yu-Chi Lin,
Nham-Linh Nguyen,
Thanh-Hoa Vo,
Yung-Yi Cheng,
Susan L. Morris-Natschke,
Kuo-Hsiung Lee,
Yao-Haur Kuo

Affiliations

Po-Yen Chen: Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Chih-Chao Chang: Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Hui-Chi Huang: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Li-Jie Zhang: Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Chia-Ching Liaw: Department of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, Taiwan
Yu-Chi Lin: Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Nham-Linh Nguyen: Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Thanh-Hoa Vo: Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
Yung-Yi Cheng: Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Susan L. Morris-Natschke: Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Kuo-Hsiung Lee: Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA
Yao-Haur Kuo: Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan

DOI: https://doi.org/10.3390/molecules24071375
Journal volume & issue: Vol. 24, no. 7
p. 1375

Abstract

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Six new dammarane-type saponins, gypenosides CP1-6 (1–6), along with 19 known compounds 7–25, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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