Nature Communications (Dec 2017)

The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks

  • Ana Teixeira-Silva,
  • Anissia Ait Saada,
  • Julien Hardy,
  • Ismail Iraqui,
  • Marina Charlotte Nocente,
  • Karine Fréon,
  • Sarah A. E. Lambert

DOI
https://doi.org/10.1038/s41467-017-02144-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Terminally arrested replication forks are restarted through homologous recombination after processing single-stranded DNA gaps. Here the authors show that resection is regulated by the NHEJ factor Ku, helping to fine-tune recombination at forks.