中枢神经系统血管炎与头痛Central Nervous System Vasculitis and Headache

Abstract

Vasculitis involving the central nervous system (CNS) is widely referred to CNS vasculitis. Headache is one of the non-specific manifestations of CNS vasculitis, and it is also the most common neurological symptom. At present, according to the 2012 Chapel Hill consensus conference (CHCC) vasculitis classification criteria, vasculitis is classified according to the size of the involved blood vessels. The pathogenesis of headaches caused by vasculitis is unknown. The destruction of the blood-brain barrier and neurovascular units may play an essential role in vasculitis-related headaches. The incidence of different types of vasculitis involving the CNS, as well as the timing and characteristics of headaches are different. It is crucial to recognize vasculitisrelated headaches and make a quick diagnosis so as to avoid unnecessary treatment or leading to severe neurological sequelae. 累及中枢神经系统的血管炎被称为中枢神经系统血管炎。头痛是中枢神经系统血管炎的非特异表现之一，也是其中最常见的神经系统症状。目前按照2012年Chapel Hill会议（Chapel Hillconsensus conference，CHCC）血管炎分类标准将血管炎按照受累血管大小不同进行分类。血管炎所致头痛的发病机制不明，血脑屏障及神经血管单元的破坏在血管炎头痛中可能起到重要作用。不同类型血管炎累及中枢神经系统的发生率以及头痛的发生时机和特点有差异。识别血管炎相关的头痛，并快速进行诊断至关重要，以免进行不必要的治疗或导致严重神经系统后遗症。不同类型血管炎所致头痛发生时机及特点有差异，血脑屏障及神经血管单元破坏在其中起重要作用。

Keywords

• 血管炎
• 中枢神经系统血管炎
• 原发性中枢神经系统血管炎
• 头痛