A second DNA binding site in human BRCA2 promotes homologous recombination

Catharina von Nicolai; Åsa Ehlén; Charlotte Martin; Xiaodong Zhang; Aura Carreira

doi:10.1038/ncomms12813

Nature Communications (Sep 2016)

A second DNA binding site in human BRCA2 promotes homologous recombination

Catharina von Nicolai,
Åsa Ehlén,
Charlotte Martin,
Xiaodong Zhang,
Aura Carreira

Affiliations

Catharina von Nicolai: Institut Curie, PSL Research University, UMR 3348, Genotoxic Stress and Cancer Unit, Research Center, Paris Sud University, Paris Saclay University, Centre Universitaire d’Orsay, Bâtiment 110
Åsa Ehlén: Institut Curie, PSL Research University, UMR 3348, Genotoxic Stress and Cancer Unit, Research Center, Paris Sud University, Paris Saclay University, Centre Universitaire d’Orsay, Bâtiment 110
Charlotte Martin: Institut Curie, PSL Research University, UMR 3348, Genotoxic Stress and Cancer Unit, Research Center, Paris Sud University, Paris Saclay University, Centre Universitaire d’Orsay, Bâtiment 110
Xiaodong Zhang: Department of Medicine, Imperial College London
Aura Carreira: Institut Curie, PSL Research University, UMR 3348, Genotoxic Stress and Cancer Unit, Research Center, Paris Sud University, Paris Saclay University, Centre Universitaire d’Orsay, Bâtiment 110

DOI: https://doi.org/10.1038/ncomms12813
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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BRCA2 is a well-characterized central player in homologous recombination in which it functions as the RAD51 loader. Here the authors identify an N-terminal region of BRCA2 that binds DNA and promotes efficient DNA repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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