Determination of statins by reverse-phase HPLC in mobile phases with diff erent modifi cation options

Abstract

The chromatographic behavior of atorvastatin, rosuvastatin and simvastatin in the presence of the main modifi ers of the mobile phase: elution strength and buff er solution, has been studied by means of the reverse-phase high-performance liquid chromatography (HPLC) method. Optimal modifi cation conditions have been found and their application for the determination of statins under study in the pharmaceutical preparations Atorvastatin-OBL, Liprimar and Tulip has been shown. The Sr value is 0.03. The relative determination error does not exceed 7%.

Keywords

• statins
• high performance liquid chromatography
• organic solvents
• buff er solutions