Nature Communications (Apr 2018)

Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting

  • Wiebke Manuela Schulze,
  • Frank Stein,
  • Mandy Rettel,
  • Max Nanao,
  • Stephen Cusack

DOI
https://doi.org/10.1038/s41467-018-04142-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Arsenic resistance protein 2 (ARS2) plays an important role in nuclear RNA metabolism and interacts with the nuclear cap-binding complex (CBC). Here the authors present the human ARS2 structure and identify regions important for its interactions with binding partners supporting that mutually exclusive higher order CBC-ARS2 complexes are formed.