The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis

Abstract

Heparan sulphate (HS)—a common cell surface decoration—is a carbohydrate of alternating sugars assembled by bi-domain enzymes such as EXTL3. Here, authors present the structure of EXTL3, explain EXTL3 lost activity, and propose that HS extension is distributive.