Nature Communications (Apr 2018)
Increased formate overflow is a hallmark of oxidative cancer
- Johannes Meiser,
- Anne Schuster,
- Matthias Pietzke,
- Johan Vande Voorde,
- Dimitris Athineos,
- Kristell Oizel,
- Guillermo Burgos-Barragan,
- Niek Wit,
- Sandeep Dhayade,
- Jennifer P. Morton,
- Emmanuel Dornier,
- David Sumpton,
- Gillian M. Mackay,
- Karen Blyth,
- Ketan J. Patel,
- Simone P. Niclou,
- Alexei Vazquez
Affiliations
- Johannes Meiser
- Cancer Research UK Beatson Institute
- Anne Schuster
- Department of Oncology, NorLux Neuro-Oncology Laboratory, Luxembourg Institute of Health
- Matthias Pietzke
- Cancer Research UK Beatson Institute
- Johan Vande Voorde
- Cancer Research UK Beatson Institute
- Dimitris Athineos
- Cancer Research UK Beatson Institute
- Kristell Oizel
- Cancer Research UK Beatson Institute
- Guillermo Burgos-Barragan
- MRC Laboratory of Molecular Biology
- Niek Wit
- MRC Laboratory of Molecular Biology
- Sandeep Dhayade
- Cancer Research UK Beatson Institute
- Jennifer P. Morton
- Cancer Research UK Beatson Institute
- Emmanuel Dornier
- Cancer Research UK Beatson Institute
- David Sumpton
- Cancer Research UK Beatson Institute
- Gillian M. Mackay
- Cancer Research UK Beatson Institute
- Karen Blyth
- Cancer Research UK Beatson Institute
- Ketan J. Patel
- MRC Laboratory of Molecular Biology
- Simone P. Niclou
- Department of Oncology, NorLux Neuro-Oncology Laboratory, Luxembourg Institute of Health
- Alexei Vazquez
- Cancer Research UK Beatson Institute
- DOI
- https://doi.org/10.1038/s41467-018-03777-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of cancer cells.
