Composição química e atividade biológica de extrato oleoso de própolis: uma alternativa ao extrato etanólico Chemical composition and biological activity of oil propolis extract: an alternative to ethanolic extract

Abstract

Propolis is mostly used as hydroalcoholic extract. Recently there has been a growing number of patents dealing with new solvents for preparing propolis extracts. This study aimed to prepare edible oil propolis extracts and compare their chemical composition and biological activity with ethanolic propolis extracts. ESI-MS and spectrophotometric methods were used for qualitative and quantitative analyses, respectively. Antibacterial activity was evaluated by diffusion in agar. Cytotoxicity was tested by MTT assay using tumor cell lines. The oil is able to extract bioactive compounds from propolis. Further studies are needed to improve extraction efficiency and to characterize the active components.

Keywords

• oil propolis extract
• phenolic compounds
• antibacterial and cytotoxic activities