Nature Communications (Jul 2020)

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

  • Afnan Abu-Thuraia,
  • Marie-Anne Goyette,
  • Jonathan Boulais,
  • Carine Delliaux,
  • Chloé Apcher,
  • Céline Schott,
  • Rony Chidiac,
  • Halil Bagci,
  • Marie-Pier Thibault,
  • Dominique Davidson,
  • Mathieu Ferron,
  • André Veillette,
  • Roger J. Daly,
  • Anne-Claude Gingras,
  • Jean-Philippe Gratton,
  • Jean-François Côté

DOI
https://doi.org/10.1038/s41467-020-17415-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 20

Abstract

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AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastasis of triple negative breast cancer cells in vivo.