Nature Communications (Apr 2022)
Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
- Zeinab Jahed,
- Yang Yang,
- Ching-Ting Tsai,
- Ethan P. Foster,
- Allister F. McGuire,
- Huaxiao Yang,
- Aofei Liu,
- Csaba Forro,
- Zen Yan,
- Xin Jiang,
- Ming-Tao Zhao,
- Wei Zhang,
- Xiao Li,
- Thomas Li,
- Annalisa Pawlosky,
- Joseph C. Wu,
- Bianxiao Cui
Affiliations
- Zeinab Jahed
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Yang Yang
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Ching-Ting Tsai
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Ethan P. Foster
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Allister F. McGuire
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Huaxiao Yang
- Stanford Cardiovascular Institute, Stanford University
- Aofei Liu
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Csaba Forro
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Zen Yan
- Cyion Technologies, LLC
- Xin Jiang
- Cyion Technologies, LLC
- Ming-Tao Zhao
- Stanford Cardiovascular Institute, Stanford University
- Wei Zhang
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Xiao Li
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Thomas Li
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- Annalisa Pawlosky
- Google Accelerated Sciences, Google LLC
- Joseph C. Wu
- Stanford Cardiovascular Institute, Stanford University
- Bianxiao Cui
- Department of Chemistry and Stanford Wu-Tsai Neuroscience Institute, Stanford University
- DOI
- https://doi.org/10.1038/s41467-022-29726-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Nanoelectrodes for measuring intracellular action potentials suffer from issues with success rate, signal strength and fabrication. Here, the authors report on a scalable technique which creates robust nanocrown electrodes with high success rates by electroporation and demonstrate the advance towards preclinical drug evaluation.
