Nature Communications (Jun 2022)
Persister state-directed transitioning and vulnerability in melanoma
- Heike Chauvistré,
- Batool Shannan,
- Sheena M. Daignault-Mill,
- Robert J. Ju,
- Daniel Picard,
- Stefanie Egetemaier,
- Renáta Váraljai,
- Christine S. Gibhardt,
- Antonio Sechi,
- Farnusch Kaschani,
- Oliver Keminer,
- Samantha J. Stehbens,
- Qin Liu,
- Xiangfan Yin,
- Kirujan Jeyakumar,
- Felix C. E. Vogel,
- Clemens Krepler,
- Vito W. Rebecca,
- Linda Kubat,
- Smiths S. Lueong,
- Jan Forster,
- Susanne Horn,
- Marc Remke,
- Michael Ehrmann,
- Annette Paschen,
- Jürgen C. Becker,
- Iris Helfrich,
- Daniel Rauh,
- Markus Kaiser,
- Sheraz Gul,
- Meenhard Herlyn,
- Ivan Bogeski,
- José Neptuno Rodríguez-López,
- Nikolas K. Haass,
- Dirk Schadendorf,
- Alexander Roesch
Affiliations
- Heike Chauvistré
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Batool Shannan
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Sheena M. Daignault-Mill
- The University of Queensland Diamantina Institute, The University of Queensland
- Robert J. Ju
- The University of Queensland Diamantina Institute, The University of Queensland
- Daniel Picard
- German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf
- Stefanie Egetemaier
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Renáta Váraljai
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Christine S. Gibhardt
- Molecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg-August-University
- Antonio Sechi
- Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School
- Farnusch Kaschani
- Department of Chemical Biology, Faculty of Biology, University of Duisburg-Essen
- Oliver Keminer
- Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
- Samantha J. Stehbens
- The University of Queensland Diamantina Institute, The University of Queensland
- Qin Liu
- The Wistar Institute
- Xiangfan Yin
- The Wistar Institute
- Kirujan Jeyakumar
- Faculty of Chemistry and Chemical Biology, TU Dortmund University
- Felix C. E. Vogel
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Clemens Krepler
- The Wistar Institute
- Vito W. Rebecca
- The Wistar Institute
- Linda Kubat
- German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf
- Smiths S. Lueong
- German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf
- Jan Forster
- German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf
- Susanne Horn
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Marc Remke
- German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf
- Michael Ehrmann
- Center for Medical Biotechnology (ZMB), University of Duisburg-Essen
- Annette Paschen
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Jürgen C. Becker
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Iris Helfrich
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Daniel Rauh
- Faculty of Chemistry and Chemical Biology, TU Dortmund University
- Markus Kaiser
- Department of Chemical Biology, Faculty of Biology, University of Duisburg-Essen
- Sheraz Gul
- Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
- Meenhard Herlyn
- The Wistar Institute
- Ivan Bogeski
- Molecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg-August-University
- José Neptuno Rodríguez-López
- GENZ-Group of Research on Enzymology, Department of Biochemistry and Molecular Biology-A, Regional Campus of International Excellence ‘Campus Mare Nostrum’, University of Murcia
- Nikolas K. Haass
- The University of Queensland Diamantina Institute, The University of Queensland
- Dirk Schadendorf
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Alexander Roesch
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- DOI
- https://doi.org/10.1038/s41467-022-30641-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Slow-cycling melanoma persister cells are characterised by a high, reversible expression of H3K4 demethylase KDM5B. Here, the authors use genetic and chemical methods to enforce a permanent high expression of KDM5B and show that these cells transit to a melanocytic differentiated state and undergo cell cycle arrest.
