Nature Communications (Aug 2017)
Retinol saturase coordinates liver metabolism by regulating ChREBP activity
- Steffi Heidenreich,
- Nicole Witte,
- Pamela Weber,
- Isabel Goehring,
- Alexander Tolkachov,
- Christian von Loeffelholz,
- Stephanie Döcke,
- Michael Bauer,
- Martin Stockmann,
- Andreas F. H. Pfeiffer,
- Andreas L. Birkenfeld,
- Matthias Pietzke,
- Stefan Kempa,
- Matthias Muenzner,
- Michael Schupp
Affiliations
- Steffi Heidenreich
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research
- Nicole Witte
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research
- Pamela Weber
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research
- Isabel Goehring
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research
- Alexander Tolkachov
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research
- Christian von Loeffelholz
- Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke
- Stephanie Döcke
- Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke
- Michael Bauer
- Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Friedrich Schiller University
- Martin Stockmann
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of General, Visceral and Transplantation Surgery
- Andreas F. H. Pfeiffer
- Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke
- Andreas L. Birkenfeld
- Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, University Clinic Dresden
- Matthias Pietzke
- Integrative Metabolomics and Proteomics, Berlin Institute of Medical Systems Biology/Max- Delbrück Center for Molecular Medicine
- Stefan Kempa
- Integrative Metabolomics and Proteomics, Berlin Institute of Medical Systems Biology/Max- Delbrück Center for Molecular Medicine
- Matthias Muenzner
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research
- Michael Schupp
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research
- DOI
- https://doi.org/10.1038/s41467-017-00430-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Fatty liver is one of the major features of metabolic syndrome and its development is associated with deregulation of systemic lipid and glucose homeostasis. Here Heidenreich et al. show that retinol saturase is implicated in hepatic lipid metabolism by regulating the activity of the transcription factor ChREBP.
