Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria

Thomas J. R. Ormsby; Sian E. Owens; Matthew L. Turner; James G. Cronin; John J. Bromfield; I. Martin Sheldon

doi:10.1038/s42003-023-04568-w

Communications Biology (Feb 2023)

Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria

Thomas J. R. Ormsby,
Sian E. Owens,
Matthew L. Turner,
James G. Cronin,
John J. Bromfield,
I. Martin Sheldon

Affiliations

Thomas J. R. Ormsby: Swansea University Medical School, Swansea University
Sian E. Owens: Swansea University Medical School, Swansea University
Matthew L. Turner: Swansea University Medical School, Swansea University
James G. Cronin: Swansea University Medical School, Swansea University
John J. Bromfield: Department of Animal Sciences, University of Florida
I. Martin Sheldon: Swansea University Medical School, Swansea University

DOI: https://doi.org/10.1038/s42003-023-04568-w
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 15

Abstract

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Treating cell lines with glucocorticoids offers protection against the damage caused by subsequent exposure to selected bacterial pore-forming toxins, and is dependent on the glucocorticoid receptor.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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